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KMID : 0880220120500020359
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Journal of Microbiology
2012 Volume.50 No. 2 p.359 ~ p.362
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GFP-expressing influenza a virus for evaluation of the efficacy of antiviral agents
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Kim Jin-Il
Park Se-Hee
Lee Il-Seob
Lee Sang-Moo
Shin Saem
Won Yong-Kwan
Hwang Min-Woong
Bae Joon-Yong
Hyun Hye-Eun
Jun Hye-jin
Park Man-Seong
Lim Soon-Sung
Heo Jun
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Abstract
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To address its value as a screening tool in the development of antiviral drugs, a recombinant influenza virus expressing green fluorescent protein (rPR8-GFP virus) was investigated in vitro and in vivo. The inhibition of viral growth by a neuraminidase inhibitor in the cells or lower respiratory tracts of mice could be visualized by the level of fluorescence. In addition, the rPR8-GFP virus exhibited high pathogenicity in mice. Taken together, these results suggest that the rPR8-GFP virus can be a useful tool for the rapid identification of antiviral drugs active against influenza viruses.
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KEYWORD
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influenza, green fluorescent protein, antiviral drug
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